Annals of family medicine
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Annals of family medicine · Jan 2015
Review Meta AnalysisEfficacy and acceptability of pharmacological treatments for depressive disorders in primary care: systematic review and network meta-analysis.
The purpose of this study was to investigate whether antidepressants are more effective than placebo in the primary care setting, and whether there are differences between substance classes regarding efficacy and acceptability. ⋯ Compared with other drugs, TCAs and SSRIs have the most solid evidence base for being effective in the primary care setting, but the effect size compared with placebo is relatively small. Further agents (hypericum, rMAO-As, SNRI, NRI, NaSSAs, SARI) showed some positive results, but limitations of the currently available evidence makes a clear recommendation on their place in clinical practice difficult.
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Annals of family medicine · Jan 2015
Review Meta AnalysisEffectiveness of psychological treatments for depressive disorders in primary care: systematic review and meta-analysis.
We performed a systematic review of the currently available evidence on whether psychological treatments are effective for treating depressed primary care patients in comparison with usual care or placebo, taking the type of therapy and its delivery mode into account. ⋯ There is evidence that psychological treatments are effective in depressed primary care patients. For CBT approaches, substantial evidence suggests that interventions that are less resource intensive might have effects similar to more intense treatments.