Journal of thrombosis and haemostasis : JTH
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J. Thromb. Haemost. · Apr 2012
Review Meta AnalysisBleeding risk in randomized controlled trials comparing warfarin and aspirin: a systematic review and meta-analysis.
Warfarin and aspirin (acetylsalicylic acid [ASA]) are the most commonly used anticoagulant and antiplatelet drugs in the treatment of cardiovascular disease. ⋯ This meta-analysis failed to find a statistically significant difference in major bleeding between warfarin, target INR 2.0-3.5, and ASA, 50-650 mg daily. The trend towards increased bleeding with warfarin appears to be explained by an excess of intracranial bleeding in warfarin patients.