Journal of thrombosis and haemostasis : JTH
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J. Thromb. Haemost. · Apr 2018
Randomized Controlled TrialAspirin withdrawal in patients treated with ticagrelor presenting with non-ST elevation myocardial infarction.
Essentials Strong P2Y12 blockade may cause platelet inhibition that is only minimally enhanced by aspirin. We evaluated aspirin withdrawal on platelet reactivity in ticagrelor treated patients. Aspirin withdrawal resulted in increased platelet reactivity to arachidonic acid. Aspirin withdrawal caused little difference in adenosine diphosphate-induced platelet aggregation.