Journal of thrombosis and haemostasis : JTH
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J. Thromb. Haemost. · Jul 2019
Multicenter Study Observational StudyDrug levels and bleeding complications in atrial fibrillation patients treated with direct oral anticoagulants.
Essentials Currently, DOACs are given at fixed doses and do not require laboratory monitoring. Direct oral anticoagulant-specific measurements were performed at trough and peak. Patients who developed bleeding events showed higher DOAC plasma levels at peak. This study suggests the need of a more accurate DOAC dose assessment.