Comptes rendus des seances de l'Academie des sciences. Serie D, Sciences naturelles
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C. R. Acad. Sci., D, Sci. Nat. · Jan 1980
[Role of serotonin in the diffuse inhibitory controls induced by nociceptive stimulation].
In the anaesthetized Rat, the entire population of dorsal horn convergent neurones is differentially affected by a noxious stimulus: while exciting the segmental pool, it strongly inhibits the remaining population. The inhibitory effects, which involve supraspinal mechanisms, are reduced to a great extent in parachlorophenylalanine pretreated animals. The role of raphé-spinal serotonergic pathways in nociception is discussed.