Circulation
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
Superiority of clopidogrel versus aspirin in patients with prior cardiac surgery.
After coronary artery bypass surgery, patients have a high cumulative rate of graft closure and recurrent ischemic events. We sought to determine whether antiplatelet therapy with clopidogrel would be more effective than aspirin, the accepted standard, in these patients. ⋯ Compared with aspirin, clopidogrel therapy results in a striking reduction in the elevated risk for recurrent ischemic events seen in patients with a history of prior cardiac surgery, along with a decreased risk of bleeding.