Circulation
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Multicenter Study Clinical Trial
B-type natriuretic peptide and clinical judgment in emergency diagnosis of heart failure: analysis from Breathing Not Properly (BNP) Multinational Study.
We sought to determine the degree to which B-type natriuretic peptide (BNP) adds to clinical judgment in the diagnosis of congestive heart failure (CHF). ⋯ The evaluation of acute dyspnea would be improved with the addition of BNP testing to clinical judgment in the emergency department.
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
Effect of implantable defibrillators on arrhythmic events and mortality in the multicenter unsustained tachycardia trial.
The Multicenter Unsustained Tachycardia Trial (MUSTT) was designed to evaluate an antiarrhythmic treatment strategy, including drugs and implantable defibrillators (ICDs), guided by electrophysiological (EP) testing. We performed several statistical analyses to assess the contribution of defibrillators to the observed treatment benefit. ⋯ The benefit of EP-guided antiarrhythmic therapy observed in MUSTT was due to improved outcomes among patients who received an ICD but not among patients who received antiarrhythmic drugs.