Circulation
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Randomized Controlled Trial Multicenter Study
Pulmonary hypertension in heart failure with preserved ejection fraction: a target of phosphodiesterase-5 inhibition in a 1-year study.
The prevalence of heart failure with preserved ejection fraction is increasing. The prognosis worsens with pulmonary hypertension and right ventricular (RV) failure development. We targeted pulmonary hypertension and RV burden with the phosphodiesterase-5 inhibitor sildenafil. ⋯ URL: http://www.clinicaltrials.gov. UNIQUE IDENTIFIER: NCT01156636.
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Multicenter Study Clinical Trial
Utility of absolute and relative changes in cardiac troponin concentrations in the early diagnosis of acute myocardial infarction.
Current guidelines for the diagnosis of acute myocardial infarction (AMI), among other criteria, also require a rise and/or fall in cardiac troponin (cTn) levels. It is unknown whether absolute or relative changes in cTn have higher diagnostic accuracy and should therefore be preferred. ⋯ URL: http://www.clinicaltrials.gov. UNIQUE IDENTIFIER: NCT00470587.