Circulation
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Randomized Controlled Trial Multicenter Study Comparative Study
Angiotensin Receptor Neprilysin Inhibitor for Functional Mitral Regurgitation.
The morbidity and mortality of patients with functional mitral regurgitation (MR) remain high, but no pharmacological therapy has been proven effective. The hypothesis of this study was that sacubitril/valsartan would be superior to valsartan alone in improving functional MR via dual inhibition of the renin-angiotensin system and neprilysin. ⋯ URL: https://www.clinicaltrials.gov . Unique identifier: NCT02687932.