Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation
-
Exp Clin Transplant · Sep 2009
Case ReportsDe novo inflammatory bowel disease after pediatric orthotopic liver transplant: a case report.
The improvement of pre-existing inflammatory bowel disease after orthotopic liver transplant might be anticipated. However, both the exacerbation of inflammatory bowel disease and de novo inflammatory bowel disease after orthotopic liver transplant (despite sufficient allograft immunosuppressive therapy) have been described. ⋯ De novo inflammatory bowel disease should be considered in patients in whom chronic diarrhea develops after an orthotopic liver transplant. We suggest that colonoscopy and biopsy should always be performed if other causes of diarrhea have been excluded.
-
Exp Clin Transplant · Sep 2009
Case ReportsLate fulminant posterior reversible encephalopathy syndrome after liver transplant.
Posterior leukoencephalopathy due to calcineurin-inhibitor-related neurotoxicity is a rare but severe complication that results from treatment with immunosuppressive agents (primarily those administered after a liver or kidney transplant). The pathophysiologic mechanisms of that disorder remain unknown. ⋯ Posterior reversible encephalopathy syndrome after liver transplant is rare. We recommend a complete cessation of any calcineurin inhibitor rather than a dose reduction.