The Journal of bone and joint surgery. American volume
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J Bone Joint Surg Am · Jul 2012
Meta AnalysisEffectiveness and safety of tranexamic acid in reducing blood loss in total knee arthroplasty: a meta-analysis.
Total knee arthroplasty is associated with substantial blood loss and the risks of transfusion. Conflicting reports have been published regarding the effectiveness and safety of tranexamic acid in reducing postoperative blood loss in total knee arthroplasty. We performed a meta-analysis to investigate the effectiveness and safety of tranexamic acid in reducing postoperative blood loss in total knee arthroplasty. ⋯ The meta-analysis shows that the use of tranexamic acid for patients undergoing total knee arthroplasty is effective and safe for the reduction of blood loss.