Acta neurochirurgica
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Acta neurochirurgica · Aug 2009
Multicenter Study Meta AnalysisInfratentorial ependymomas: prognostic factors and outcome analysis in a multi-center retrospective series of 106 adult patients.
This study was undertaken to analyze outcomes and to assess the prognostic impact of age, location, surgery, radiotherapy (RT), and histopathology in a series of adult infratentorial ependymomas. ⋯ This study highlights the key role of histology in the clinical outcome and the fact that gross total resection is a main prognostic factor and the treatment of choice for posterior fossa ependymomas. The use of adjuvant RT in patients with incompletely resected WHO grade II ependymomas appears beneficial, but its effect on high-grade tumors remains to be determined.