Arthritis & rheumatology (Hoboken, N.J.)
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Arthritis Rheumatol · Dec 2014
Meta AnalysisMeta-analysis of assay sensitivity and study features in clinical trials of pharmacologic treatments for osteoarthritis pain.
To identify patient, study, and site factors associated with assay sensitivity in clinical trials of pharmacologic treatments for osteoarthritis (OA) pain. ⋯ The analyses examined potentially modifiable correlates of study SES and showed that longer treatment durations and allowing concomitant analgesics in randomized clinical trials of OA pain are associated with reduced assay sensitivity. These data provide a foundation for investigating strategies to improve assay sensitivity and thereby decrease the likelihood of false-negative outcomes in randomized clinical trials of efficacious treatments for OA pain.