Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
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Review Meta Analysis
Medium Increased Risk for Central Sleep Apnea but Not Obstructive Sleep Apnea in Long-Term Opioid Users: A Systematic Review and Meta-Analysis.
Opioids are associated with higher risk for ataxic breathing and sleep apnea. We conducted a systematic literature review and meta-analysis to assess the influence of long-term opioid use on the apnea-hypopnea and central apnea indices (AHI and CAI, respectively). ⋯ The meta-analysis results suggest that long-term opioid use in OSA patients has a medium effect on central sleep apnea.