Journal of Zhejiang University. Science. B
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J Zhejiang Univ Sci B · Sep 2005
Randomized Controlled Trial Clinical TrialDose requirements of continuous infusion of rocuronium and atracurium throughout orthotopic liver transplantation in humans.
To compare the dose requirements of continuous infusion of rocuronium and atracurium throughout orthotopic liver transplantation (OLT) in humans. ⋯ This study showed that the exclusion of the liver from the circulation results in the significantly reduced requirement of rocuronium while the requirement of atracurium was not changed, which suggests that the liver is of major importance in the clearance of rocuronium. A continuous infusion of atracurium with constant rate can provide stable neuromuscular blockade during the three stages of OLT.