Journal of biomechanics
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Journal of biomechanics · Sep 2013
ReviewWhat have we learned from finite element model studies of lumbar intervertebral discs in the past four decades?
Finite element analysis is a powerful tool routinely used to study complex biological systems. For the last four decades, the lumbar intervertebral disc has been the focus of many such investigations. To understand the disc functional biomechanics, a precise knowledge of the disc mechanical, structural and biochemical environments at the microscopic and macroscopic levels is essential. ⋯ The role of fluid pressurization and collagen fiber stiffening diminish with time during diurnal loading. The endplates permeability influences the time-dependent response of the disc in both loaded and unloaded recovery phases. The transport of solutes is substantially influenced by the disc size, tissue diffusivity and endplates permeability.