Contemporary clinical trials
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Contemp Clin Trials · Feb 2006
ReviewThe use of unequal randomisation ratios in clinical trials: a review.
To examine reasons given for the use of unequal randomisation in randomised controlled trials (RCTs). ⋯ Although unequal randomisation offers a number of advantages to trials the method is rarely used and is especially under-utilised to reduce trial costs. Unequal randomisation should be considered more in trial design especially where there are large differences between treatment costs.