International heart journal
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Review Meta Analysis
Liberal versus restricted fluid administration in heart failure patients. A systematic review and meta-analysis of randomized trials.
Restrictive fluid intake is recommended, in addition to standard pharmacologic treatment, in the treatment of patients with chronic heart failure (CHF). However, this recommendation lacks firm scientific evidence. We conducted a systematic review and meta-analysis of published randomized controlled trials to estimate the effect of fluid restriction in patients with heart failure. ⋯ There was no difference in any of the outcomes after correcting for heterogeneity. While studies to date are limited by heterogeneity and small sample sizes, the combined data suggest similar clinical outcomes in patients with CHF managed with liberal and restrictive fluid intake. Larger studies are needed to confirm our findings.