Journal of cardiovascular medicine
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J Cardiovasc Med (Hagerstown) · Feb 2014
Multicenter StudyRole of hypertension on new onset congestive heart failure in patients receiving trastuzumab therapy for breast cancer.
Adjuvant trastuzumab therapy improves survival of Human Epidermal growth factor receptor 2 (HER2)-positive women with early breast cancer (EBC). Trastuzumab-induced cardiotoxicity is not uncommon. In the setting of community patients, the incidence, timing and phenotype of new onset congestive heart failure (CHF) is unknown. ⋯ New onset CHF occurs seldom in HER2-positive women with EBC, prevalently in the first 6 months of therapy. CHF is associated with a significant reduction in LVEF and is predicted by a history of hypertension.