Internal and emergency medicine
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Behçet syndrome is a systemic inflammatory disorder characterized by multiorgan involvement such as oral and genital ulcers, uveitis, skin lesions as well as by less frequent, but often more severe, central nervous system and vascular manifestations. The pathogenetic mechanisms are still incompletely known; however the interaction between a specific genetic background and environmental or infectious factors certainly contributes to the immune dysregulation that characterizes this disease. The discovery of new immunological pathways in Behçet syndrome pathogenesis may help us to set up new treatments. In this review, we will focus our attention on the possible mechanisms underlying Behçet syndrome pathogenesis and their potential role as novel therapeutic targets.
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Review Case Reports
Anaphylaxis caused by intravenous fluorescein: clinical characteristics and review of literature.
Anaphylaxis is a severe, potentially fatal, systemic allergic reaction that suddenly occurs after contact with an allergy-causing substance. The aims of this study were to evaluate the clinical characteristics and outcomes of patients who were diagnosed with anaphylaxis to fluorescein. The medical records of patients with anaphylaxis to intravenous fluorescein angiography (IVFA) admitted to the emergency department between January 2010 and June 2012 were retrospectively reviewed. ⋯ All of our patients recovered without sequelae and mortality following prompt and proper intervention. Although the incidence is low, anaphylaxis due to intravenous fluorescein can occur during IVFA. Physicians should be aware of this possible complication, and be prepared to treat it.
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Review Historical Article
Coeliac disease: an old or a new disease? History of a pathology.
The celiac disease is an ancient pathology, present since the introduction of the wheat in the diet, of which the first description of the compatible clinical symptoms and signs goes back to 250 A. D. ⋯ Re-evaluating the clinical and instrumental methods for the diagnosis of Celiac Disease, and benefitting from the most modern techniques for the morphological, biochemical and genetic study of the patients, we sought to understand whether the incidence of the disease is actually increased or if has been considered less frequent for the lower valuation of the signs once deemed more atypical, but currently considered preliminary indicative of the pathology, for its association with other autoimmune diseases, and for the study of some genetic and familiar characteristics. Each of these factors has led the modern medicine to increase epidemiological studies and expand the research potential carriers of celiac disease with safer diagnostic tests.