Clinical research in cardiology : official journal of the German Cardiac Society
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Randomized Controlled Trial Multicenter Study
Impact of renal function on clinical outcomes after PCI in ACS and stable CAD patients treated with ticagrelor: a prespecified analysis of the GLOBAL LEADERS randomized clinical trial.
Impaired renal function (IRF) is associated with increased risks of both ischemic and bleeding events. Ticagrelor has been shown to provide greater absolute reduction in ischemic risk following acute coronary syndrome (ACS) in those with versus without IRF. ⋯ The trial has been registered with ClinicalTrials.gov, number NCT01813435.