Obesity
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Randomized Controlled Trial Multicenter Study
Evaluation of phentermine and topiramate versus phentermine/topiramate extended-release in obese adults.
A 28-week, randomized, controlled trial compared the combination of phentermine and topiramate extended-release (PHEN/TPM ER) with its components as monotherapies and with placebo in obese adults. ⋯ PHEN/TPM ER demonstrated greater WL when used in combination than when used as monotherapies, suggesting enhanced ability of the combination formulation to induce WL at doses lower than with available monotherapies.