Clinical journal of the American Society of Nephrology : CJASN
-
Clin J Am Soc Nephrol · Jul 2013
Randomized Controlled TrialEffects of cholecalciferol on functional, biochemical, vascular, and quality of life outcomes in hemodialysis patients.
Observational studies suggest that calciferol supplementation may improve laboratory and patient-level outcomes of hemodialysis patients with reduced 25-hydroxyvitamin D [25(OH)D] levels. This randomized controlled trial examined effects of cholecalciferol supplementation in patients on hemodialysis. ⋯ In this randomized controlled trial, patients supplemented with cholecalciferol had higher 25(OH)D, 1,25-dihydroxyvitamin D, and tartrate-resistant acid phosphatase-5b levels, without increased calcium or phosphorus values. However, no effects were detected in muscle strength, functional capacity, PWV, or HRQOL.