Clinical journal of the American Society of Nephrology : CJASN
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Clin J Am Soc Nephrol · Sep 2013
Multicenter StudyAssociation of nocturnal hypoxemia with progression of CKD.
Nocturnal hypoxemia is highly prevalent among patients with CKD. Nocturnal hypoxemia contributes to systemic inflammation, oxidative stress, endothelial cell dysfunction, and activation of the renin-angiotensin system, which are common pathologic mechanisms of CKD progression. This study investigated whether nocturnal hypoxemia is independently associated with CKD progression. ⋯ In nonobese patients with CKD, nocturnal hypoxemia is an independent risk factor of a rapid decline in kidney function.