Vascular health and risk management
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Vasc Health Risk Manag · Jan 2009
Randomized Controlled TrialEffects of allopurinol and vitamin E on renal function in patients with cardiac coronary artery bypass grafts.
Acute renal failure is a common complication of cardiac surgery, with oxidants found to play an important role in renal injury. We therefore assessed whether the supplemental antioxidant vitamin E and the inhibitor of xanthine oxidase allopurinol could prevent renal dysfunction after coronary artery bypass graft (CABG) surgery. ⋯ Prophylactic treatment with vitamin E and allopurinol had no renoprotective effects in patients with pre-existing renal failure undergoing CABG surgery. Treatment with these agents, however, reduces the duration of ICU stay.