Vascular health and risk management
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Vasc Health Risk Manag · Jan 2010
Randomized Controlled Trial Comparative StudyComparison of once-daily versus twice-daily dosing of valsartan in patients with chronic stable heart failure.
The safety of once-daily (qd) dosing of valsartan in heart failure (HF) patients is not known. ⋯ Valsartan administered qd has a similar safety and tolerability profile with comparable 24-hour RAAS blockade, as assessed by increases in PRA, as bid dosing in patients with moderate to severe (NYHA class II-III) heart failure.