Future microbiology
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Future microbiology · Jan 2015
ReviewSystematic review on intervention with prebiotics/probiotics in patients with obesity-related nonalcoholic fatty liver disease.
The gut microbiota is modulated by metabolic derangements, such as nutrition overload and obesity. ⋯ Although probiotics and prebiotics have been proposed in the treatment and prevention of patients with obesity-related NAFLD, their therapeutic use is not supported by high-quality clinical studies.
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Future microbiology · Jan 2015
ReviewSystematic review on intervention with prebiotics/probiotics in patients with obesity-related nonalcoholic fatty liver disease.
The gut microbiota is modulated by metabolic derangements, such as nutrition overload and obesity. ⋯ Although probiotics and prebiotics have been proposed in the treatment and prevention of patients with obesity-related NAFLD, their therapeutic use is not supported by high-quality clinical studies.
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Future microbiology · Jan 2015
ReviewClinical development of RTS,S/AS malaria vaccine: a systematic review of clinical Phase I-III trials.
The first clinical Phase III trial evaluating a malaria vaccine was completed in December 2013 at 11 sites from seven sub-Saharan African countries. This systematic review assesses data of Phase I-III trials including malaria-naive adults and adults, children and infants from malaria endemic settings in sub-Saharan Africa. ⋯ The RTS,S/AS01 malaria vaccine may become available on the market in the coming year. If so, further strategies should address challenges on how to optimize vaccine efficacy and implementation of RTS,S/AS01 vaccine within the framework of established malaria control measures.