ACS chemical biology
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ACS Chem. Biol.
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ACS chemical biology · Mar 2016
ReviewSAM/SAH Analogs as Versatile Tools for SAM-Dependent Methyltransferases.
S-Adenosyl-L-methionine (SAM) is a sulfonium molecule with a structural hybrid of methionine and adenosine. As the second largest cofactor in the human body, its major function is to serve as methyl donor for SAM-dependent methyltransferases (MTases). ⋯ Meanwhile, new compounds built upon or derived from the SAM scaffold have been designed and tested as selective inhibitors for important MTase targets. Here, we summarized the recent development and application of SAM analogs as chemical biology tools for MTases.