Medicina
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Multicenter Study Observational Study
Vaccination impact: mortality and time shift to COVID-19 maximum severity in hospitalized patients. An Argentine multicenter registry.
The COVID-19 vaccine became an effective instrument to prevent severe SARS-CoV-2 infections. However, 5% of vaccinated patients will have moderate or severe disease. ⋯ The time elapsed between the onset of COVID-19 symptoms to the highest severity was similar in vaccinated and unvaccinated patients. However, hospitalized vaccinated patients had a lower risk of mortality than unvaccinated patients.
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Multicenter Study
[Venous and cerebral sinus thrombosis in newborns and children].
Cerebral venous sinus thrombosis (CVST) is a well-known, although underestimated, cause of stroke in childhood. Its diagnosis requires a high index of suspicion, a correct interpretation of neuroimaging studies and an interrelation between clinicians and radiologists. The clinical features, risk factors and neuroimaging of children under 15 years of age with CVST were analyzed. ⋯ To make an early diagnosis, it is essential to consider CVST in newborns with encephalopathic symptoms and/or seizures, and in children with signs of ICH in the presence of predisposing or triggering conditions.
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Multicenter Study
[Early use of tocilizumab in hospitalized patients with severe and critical COVID-19 in the Province of Buenos Aires: a multicentric study].
Tocilizumab (TCZ), an IL-6 receptor antagonist monoclonal antibody is warranted in severe and critically-ill COVID-19 patients. The objective was to evaluate 28-day mortality of patients with severe or critical COVID-19 treated with early vs delayed TCZ. ⋯ This study supports the early use of TCZ in patients with severe or critical COVID-19.
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Multicenter Study
Clinical features and outcomes of diabetic foot in Argentina: a longitudinal multicenter study.
The diabetic foot (DF) is a complication with high rate of morbi-mortality. There are no data about amputation rates and mortality in Argentina related to this disease. The aim of this study was to describe clinical features of adult patients with diabetes that consulted for a foot ulcer in a 3 months' period and to evaluate outcomes six months later. ⋯ Knowledge about local data will enable better decisions on health policies related to prevention and treatment of diabetic foot patients.
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Clinical features and outcomes of SARSCoV-2 infections may change between different waves of the pandemic. The objective of this study was to compare clinical characteristics and outcomes between two cohorts of patients hospitalized for COVID-19 during the first and second waves in Argentina. ⋯ Compared to patients admitted during the first wave, patients admitted with SARS-CoV2 during the second wave in Argentina were more seriously ill and had a higher mortality.