JACC. Cardiovascular interventions
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JACC Cardiovasc Interv · Nov 2009
Comment Review Meta AnalysisSodium bicarbonate plus N-acetylcysteine prophylaxis: a meta-analysis.
We sought to conduct a meta-analysis to compare N-acetylcysteine (NAC) in combination with sodium bicarbonate (NaHCO(3)) for the prevention of contrast-induced acute kidney injury (AKI). ⋯ Combination prophylaxis with NAC and NaHCO(3) substantially reduced the occurrence of contrast-induced AKI overall but not dialysis-dependent renal failure. Combination prophylaxis should be incorporated for all high-risk patients (emergent cases or patients with chronic kidney disease) and should be strongly considered for all interventional radio-contrast procedures.