Circulation. Cardiovascular genetics
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Circ Cardiovasc Genet · Oct 2014
Meta AnalysisMultiple associated variants increase the heritability explained for plasma lipids and coronary artery disease.
Plasma lipid levels as well as coronary artery disease (CAD) have been shown to be highly heritable with estimates ranging from 40% to 60%. However, top variants detected by large-scale genome-wide association studies explain only a fraction of the total variance in plasma lipid phenotypes and CAD. ⋯ These results demonstrate that a portion of the missing heritability for lipid traits and CAD can be explained by multiple variants at each locus.