Journal of bronchology & interventional pulmonology
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J Bronchology Interv Pulmonol · Oct 2014
Randomized Controlled Trial Multicenter StudyThe IBV Valve trial: a multicenter, randomized, double-blind trial of endobronchial therapy for severe emphysema.
Lung volume reduction surgery improves quality of life, exercise capacity, and survival in selected patients but is accompanied by significant morbidity. Bronchoscopic approaches may provide similar benefits with less morbidity. ⋯ This trial had technical and statistical success but partial-bilateral endobronchial valve occlusion did not obtain clinically meaningful results. Safety results were acceptable and compare favorably to lung volume reduction surgery and other bronchial valve studies. Further studies need to focus on improved patient selection and a different treatment algorithm.