Arthritis care & research
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Arthritis care & research · Nov 2014
Randomized Controlled Trial Multicenter StudySubcutaneous tocilizumab versus placebo in combination with disease-modifying antirheumatic drugs in patients with rheumatoid arthritis.
The efficacy and safety of subcutaneous tocilizumab (TCZ-SC) versus subcutaneous placebo (PBO-SC) was evaluated in patients with rheumatoid arthritis who had an inadequate response to disease-modifying antirheumatic drugs in the BREVACTA study. ⋯ TCZ-SC every other week had significantly greater efficacy, including ACR end points and inhibition of joint damage, compared with PBO-SC. TCZ-SC was well tolerated and its safety profile was comparable with that of previous intravenous TCZ studies.
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Arthritis care & research · Nov 2014
Randomized Controlled TrialFunctional discharge readiness and mobility following total knee arthroplasty for osteoarthritis: a comparison of analgesic techniques.
To determine if functional discharge readiness and mobility following total knee arthroplasty (TKA) for osteoarthritis is delayed after femoral nerve block (FNB) with or without patient-controlled analgesia (PCA) opioid compared with PCA opioid alone. ⋯ After TKA, FNB (single-injection with PCA opioid or continuous) does not delay achievement of 90° knee flexion or other measures of functional discharge readiness and mobility compared with PCA opioid alone.