Injury
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Randomized Controlled Trial
Gender differences in outcome in patients with hypotension and severe traumatic brain injury.
Animal studies have identified hormonal influences on responses to injury and recovery, creating a potential gender effect on outcome. Progesterone and oestrogen are thought to afford protection in the immediate post-injury period, suggesting females have an advantage, although there has been limited evidence of this in human outcome studies. ⋯ The study provides no evidence that females fare better than males following severe TBI, suggesting rather that females may fare worse.