Journal of hepato-biliary-pancreatic sciences
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J Hepatobiliary Pancreat Sci · Mar 2012
Randomized Controlled Trial Comparative StudyIschemic preconditioning prior to intermittent Pringle maneuver in liver resections.
Continuous inflow vascular occlusion during liver resections causes less severe ischemia and reperfusion injury (IRI) if it is preceded by ischemic preconditioning (IP) or if intermittent inflow occlusion is used during the resection. No previous clinical trial has studied the effects of adding IP to intermittent inflow occlusion. ⋯ IP before intermittent vascular occlusion does not reduce the serum parameters used to assess IRI. IP seems to improve aerobic glucose metabolism, as the levels of glucose, pyruvate, and lactate locally in the liver were reduced, compared to controls, in patients having >3 segments resected. μD may be used to monitor metabolism locally.