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Chest
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Randomized Controlled Trial Clinical Trial
The effect of short-term instillation of a mucolytic agent (mesna) on airway resistance in mechanically ventilated patients.
To determine whether bolus instillation of a mucolytic agent (mesna) could diminish airway resistance, endotracheal tube resistance, or both in patients mechanically ventilated for acute respiratory failure. ⋯ In our patients, bolus tracheal instillation of mesna does not improve airway resistance; in fact, mesna instillation induces episodes of bronchospasm that disappear 2 h later.