Chest
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Review Meta Analysis
Continuous vs intermittent beta-agonists in the treatment of acute adult asthma: a systematic review with meta-analysis.
Since the late 1980s, there has been considerable clinical and academic interest in the use of continuous aerosolized bronchodilators for the treatment of patients with acute asthma. These studies have suggested that this therapy is safe, is at least as effective as intermittent nebulization, and may be superior to intermittent nebulization in patients with the most severely impaired pulmonary function. ⋯ Overall, this review supports the equivalence of continuous and intermittent albuterol nebulization in the treatment of acute adult asthma.
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Meta Analysis
Bronchoprotective effects of leukotriene receptor antagonists in asthma: a meta-analysis.
Cysteinyl leukotrienes are important proinflammatory mediators in the pathogenesis of asthma. Since bronchial hyperresponsiveness is a noninvasive surrogate marker of asthmatic airway inflammation, we evaluated the bronchoprotection afforded by leukotriene receptor antagonists (LTRAs). ⋯ Since the estimated protection amounted to almost one doubling dose, this reinforces the role of LTRAs as anti-inflammatory therapy in asthma.