Chest
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ABSTRACT BACKGROUND. Lung cancer is the leading cause of cancer deaths in both genders worldwide, with an incidence only second to prostate cancer in men and breast cancer in women. The lethality of the disease highlights the urgent need for innovative therapeutic options. ⋯ CONCLUSIONS. Our results provide proof of principle that the CTAs SP17/AKAP4/PTTG1 are expressed in both human NSCLC cell lines and primary tumors and can elicit an immunogenic response in NSCLC patients. Based on our findings, further studies are warranted to explore the feasibility of developing CTA-specific immunotherapeutic strategies for NSCLC patients.
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Randomized Controlled Trial Multicenter Study
Multidisciplinary Approach to Management of Maternal Asthma (MAMMA): A Randomized Controlled Trial.
Maternal asthma control may be improved by multidisciplinary care, education and asthma monitoring.
pearl -
Review Meta Analysis
Comparative Effectiveness and Safety of Drug Therapy for Pulmonary Arterial Hypertension: A Systematic Review and Meta-Analysis.
Drug treatment for pulmonary hypertension improved 6-minute walk distance and reduced hospitalisation. Combination is more effective than monotherapy.
pearl -
Randomized Controlled Trial Multicenter Study
Accuracy of point-of-care multiorgan ultrasonography for the diagnosis of pulmonary embolism.
Presenting signs and symptoms of pulmonary embolism (PE) are nonspecific, favoring a large use of second-line diagnostic tests such as multidetector CT pulmonary angiography (MCTPA), thus exposing patients to high-dose radiation and to potential serious complications. We investigated the diagnostic performance of multiorgan ultrasonography (lung, heart, and leg vein ultrasonography) and whether multiorgan ultrasonography combined to Wells score and D-dimer could safely reduce MCTPA tests. ⋯ Multiorgan ultrasonography is more sensitive than single-organ ultrasonography, increases the accuracy of clinical pretest probability estimation in patients with suspected PE, and may safely reduce the MCTPA burden.
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Randomized Controlled Trial
The emotional and cognitive impact of unexpected simulated patient death: a randomized controlled trial.
Observational studies suggest that emotions experienced during simulation training may affect cognitive load and learning outcomes. The objective of this study was to manipulate emotions during simulation training and assess the impact on cognitive load and learning. ⋯ Students exposed to unexpected simulated patient death reported increased cognitive load and had poorer learning outcomes. Educators need to expose learners to negative experiences; therefore, further studies are needed on how best to use negative emotional experiences during simulation training.