Chest
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Randomized Controlled Trial
Pregabalin and speech pathology combination therapy for refractory chronic cough: A randomised controlled trial.
Chronic refractory cough (CRC) is a difficult problem to treat. Speech pathology treatment (SPT) improves symptoms but resolution is incomplete. Centrally acting neuromodulators also improve cough symptoms, but not cough reflex sensitivity, and the effect is short-lived. We hypothesized that combined SPT and centrally acting neuromodulators would have a superior outcome than SPT alone. Our goal was to determine whether combined pregabalin and SPT is more effective than SPT alone. ⋯ Combined SPT and pregabalin reduces symptoms and improves QOL compared with SPT alone in patients with CRC.