Chest
-
Randomized Controlled Trial
Targeted Temperature Management after In-Hospital Cardiac Arrest: An Ancillary Analysis of HYPERION Trial Data.
Targeted temperature management (TTM) currently is the only treatment with demonstrated efficacy in attenuating the harmful effects on the brain of ischemia-reperfusion injury after cardiac arrest. However, whether TTM is beneficial in the subset of patients with in-hospital cardiac arrest (IHCA) remains unclear. ⋯ Hypothermia at 33 °C was associated with better day 90 neurologic outcomes after IHCA in a nonshockable rhythm compared with TN. However, the limited sample size resulted in wide CIs. Further studies of patients after cardiac arrest resulting from any cause, including IHCA, are needed.
-
Randomized Controlled Trial Multicenter Study
Results of a phase 2b trial with GB001, a DP2 antagonist, in moderate-to-severe eosinophilic asthma.
Prostaglandin D2 receptor 2 (DP2) antagonists inhibit prostaglandin D2-induced effects, including recruitment and activation of cells driving asthma pathogenesis. However, challenges identifying target population and end points persist. ⋯ gov.
-
Randomized Controlled Trial
Optimizing COPD Acute Care Patient Outcomes Using a Standardized Transition Bundle and Care-Coordinator: A Randomized Clinical Trial.
Acute exacerbations of COPD (AECOPD) are associated with high morbidity and mortality and frequent readmissions. ⋯ The COPD transition bundle reduced 7- and 30-day hospital readmissions while increasing LOS and ED revisits. The care coordinator did not improve outcomes.