Chest
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Multicenter Study
A Large-Scale Multi-Center Retrospective Study on Nephrotoxicity Associated with Empiric Broad Spectrum Antibiotics in Critically Ill Patients.
Evidence regarding acute kidney injury associated with concomitant administration of vancomycin and piperacillin-tazobactam is conflicting, particularly in patients in the ICU. ⋯ VPT is associated with a higher risk of acute kidney injury than both vancomycin and cefepime and vancomycin and meropenem in patients in the ICU, especially for patients with normal initial kidney function requiring longer durations of therapy. Clinicians should consider vancomycin and meropenem or vancomycin and cefepime to reduce the risk of nephrotoxicity for patients in the ICU.
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Randomized Controlled Trial Multicenter Study
The OaSiS Trial (WF-20817CD): Multi-Center Randomized Effectiveness Implementation Trial to Increase Smoking Cessation for Individuals Undergoing Lung Screening.
One-half of all people who undergo lung cancer screening (LCS) currently use tobacco. However, few published studies have explored how to implement effective tobacco use treatment optimally during the LCS encounter. ⋯ The OaSiS trial participants showed a significant reduction in tobacco use over time, but no difference by trial arm was found.
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Multicenter Study
Polysomnographic Assessment of Sleep Disturbances in Cancer Development: A Historical Multicenter Clinical Cohort Study.
Many cellular processes are controlled by sleep. Therefore, alterations in sleep might be expected to stress biological systems that could influence malignancy risk. ⋯ In a large cohort, we confirmed the importance of polysomnographic phenotypes and highlighted the role that PLMS and oxygenation desaturation may play in cancer. Using this study's findings, we also developed an Excel (Microsoft) spreadsheet (polysomnography cluster classifier) that can be used to validate the identified clusters on new data or to identify which cluster a patient belongs to.
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Multicenter Study Observational Study
Respiratory support techniques for COVID-19-related ARDS in a sub-Saharan African country: A multi-center observational study.
Limited data from low-income countries report on respiratory support techniques in COVID-19-associated ARDS. ⋯ SOX, HFNO, CPAP, NIV, and IMV were used as respiratory support techniques in patients with COVID-19-associated ARDS in Uganda. Although these data are observational, they suggest that the use of SOX and HFNO therapy as well as awake proning are associated with a lower mortality resulting from COVID-19-associated ARDS in a resource-limited setting.