International journal of clinical pharmacy
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Meta Analysis
Influence of dexmedetomidine on cardiac complications in non-cardiac surgery: a meta-analysis of randomized trials.
Background The cardiac protection of dexmedetomidine (Dex) in peri-operative period of patients with non-cardiac surgery is still controversial. Aim of the Review We aimed to evaluate the influence of Dex on cardiac complications in peri-operative period of non-cardiac surgery by using a meta-analysis. Methods PubMed, Embase, the Cochrane library and Springer databases were searched for relevant studies. ⋯ In subgroup analysis, the risk of bradycardia was significantly higher in 1.0 μg/kg Dex group than that in placebo group. Besides, a higher risk of hypotension in 0.5 μg/kg Dex group than that in placebo group was found. Conclusions Dex supplement might not reduce the risk of cardiac complications but increases the risk of hypotension and bradycardia in peri-operative period of patients who underwent non-cardiac surgeries.