The journal of trauma and acute care surgery
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J Trauma Acute Care Surg · Dec 2015
Randomized Controlled Trial Comparative StudyHeparin versus enoxaparin for prevention of venous thromboembolism after trauma: A randomized noninferiority trial.
Research comparing enoxaparin with unfractionated heparin (UFH) given every 12 hours for venous thromboembolism (VTE) prophylaxis after trauma overlooks original recommendations that UFH be given every 8 hours. We conducted a prospective, randomized, noninferiority trial comparing UFH every 8 hours and standard enoxaparin every 12 hours. We hypothesized that the incidence of VTE in trauma patients receiving UFH every 8 hours would be no more than 10% higher than that in patients receiving enoxaparin every 12 hours. ⋯ Therapeutic/care management study, level II.