The journal of trauma and acute care surgery
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J Trauma Acute Care Surg · Mar 2013
Randomized Controlled Trial Comparative StudyUrinary proteomics analysis for sepsis biomarkers with iTRAQ labeling and two-dimensional liquid chromatography-tandem mass spectrometry.
Proteomics has only recently been applied to the field of critical care research. Sepsis is a major factor contributing to intensive care unit admissions and deaths. The purpose of this study was to screen potential urinary biomarkers for sepsis using A proteomics approach. ⋯ Diagnostic study, level IV.
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J Trauma Acute Care Surg · Mar 2013
Randomized Controlled Trial Multicenter Study Comparative StudyA prospective multicenter comparison of levetiracetam versus phenytoin for early posttraumatic seizure prophylaxis.
Brain Trauma Foundation guidelines recommend seizure prophylaxis for preventing early posttraumatic seizure (PTS). Phenytoin (PHE) is commonly used. Despite a paucity of data in traumatic brain injury, levetiracetam (LEV) has been introduced as a potential replacement, which is more costly but does not require serum monitoring. The purpose of this study was to compare the efficacy of PHE with that of LEV for preventing early PTS. ⋯ Therapeutic study, level III.
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J Trauma Acute Care Surg · Mar 2013
Randomized Controlled Trial Multicenter StudyOccult pneumothoraces in critical care: a prospective multicenter randomized controlled trial of pleural drainage for mechanically ventilated trauma patients with occult pneumothoraces.
Patients with an occult pneumothoraces (OPTXs) may be at risk of tension pneumothoraces (TPTXs) without drainage or pleural drainage complications if treated. ⋯ Therapeutic study, level III.
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J Trauma Acute Care Surg · Feb 2013
Randomized Controlled Trial Comparative StudyCryopreserved deglycerolized blood is safe and achieves superior tissue oxygenation compared with refrigerated red blood cells: a prospective randomized pilot study.
During preservation, donated liquid red blood cells (RBCs) experience multiple functional and structural changes known as the storage lesion. Increased RBC age is associated with increased infection rates, organ failure, and mortality. ⋯ Therapeutic study, level II.
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J Trauma Acute Care Surg · Jan 2013
Randomized Controlled Trial Comparative StudyProspective comparison of packed red blood cell-to-fresh frozen plasma transfusion ratio of 4: 1 versus 1: 1 during acute massive burn excision.
Acute burn excision results in at least 2% blood volume loss per percent excised; hence, massive blood loss (>50% total blood volume) occurs during major burn excisions. The purpose of this pilot study was to assess safety and prospectively compare the impact of a 4:1 versus a 1:1 packed red blood cell-fresh frozen plasma (PRBC/FFP) transfusion strategy on outcomes in children with burns greater than 20% total body surface area (TBSA). ⋯ Therapeutic, level II.