Postgraduate medical journal
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Statin use is associated with decreased COVID mortality.
pearl -
Meta Analysis Controlled Clinical Trial
Sofosbuvir with daclatasvir and the outcomes of patients with COVID-19: a systematic review and meta-analysis with GRADE assessment.
This systematic review and meta-analysis aimed to evaluate the effect of sofosbuvir/daclatasvir (SOF/DCV) on mortality, the need for intensive care unit (ICU) admission or invasive mechanical ventilation (IMV) and clinical recovery in patients with COVID-19. ⋯ PROSPERO: CRD42021247510.
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CT is widely used for diagnosis, staging and management of cancer. The presence of metastasis has significant implications on treatment and prognosis. ⋯ A total of 29 studies were included which could be grouped together into three areas of research: the use of deep learning on the detection of metastatic disease from CT imaging, characterisation of lesions on CT into metastasis and prediction of the presence or development of metastasis based on the primary tumour. In conclusion, DL in CT image analysis could have a potential role in evaluating metastatic disease; however, prospective clinical trials investigating its clinical value are required.
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Telephone consultations are already employed in specific neurological settings. At Cambridge University Hospitals, the COVID-19 pandemic initially prompted almost all face-to-face appointments to be delivered by telephone, providing a uniquely unselected population to assess. ⋯ Telephone consultations appear effective, convenient and popular in prespecified subgroups of neurological outpatients. Further work comparing telephone, video and face-to-face consultations across multiple centres is now needed.