Postgraduate medical journal
The most recent articles from:
Postgrad Med J
-
Review Meta Analysis
Systematic review and meta-analysis of the effects of antipyretic medications on mortality in Streptococcus pneumoniae infections.
To determine whether the use of antipyretic medications in the treatment of Streptococcus pneumoniae infection affects mortality in humans or animal models. ⋯ A twofold increased risk of mortality was found with aspirin treatment in animal models of S pneumoniae infection. No relevant human studies were identified. It is difficult to generalise from animal models to clinical medicine, but based on these findings and the prevalence and severity of S pneumoniae infections worldwide, future study of the effects of antipyretic therapy in S pneumoniae infection in humans is recommended.