Postgraduate medical journal
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Randomized Controlled Trial
Effect of methionine loading on pulse wave analysis in elderly volunteers.
To test the hypothesis that an acute increase in plasma homocysteine produced by methionine is associated with an acute increase in pulse wave velocity. ⋯ In elderly volunteers, acute hyperhomocysteinaemia induced by methionine loading resulted in no overall significant delayed reduction in peripheral arterial distensibility. A significant deterioration in the lipid profile and increased blood pressure was seen during acute hyperhomocysteinaemia.
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Randomized Controlled Trial Comparative Study Clinical Trial
Rofecoxib versus ibuprofen for acute treatment of migraine: a randomised placebo controlled trial.
Rofecoxib is a potent cyclo-oxygenase-2 inhibitor with a long duration of action. Its role in migraine has not been systematically evaluated. ⋯ Both ibuprofen and rofecoxib were superior to placebo in aborting an acute migraine attack, and there was no significant difference in their efficacy in an acute migraine attack.
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Randomized Controlled Trial Clinical Trial
Single megadose vitamin A supplementation of Indian mothers and morbidity in breastfed young infants.
In developing countries low maternal vitamin A stores combined with increased demands of pregnancy and lactation may lead to its deficiency in breastfed infants. This study evaluates the effects of maternal supplementation with a high dose of vitamin A on the serum retinol levels of exclusively breastfed infants, and their morbidity in the first six months of life. ⋯ Maternal supplementation with single megadose vitamin A is an effective strategy for vitamin A prophylaxis of exclusively breastfed infants of 0-6 months.
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Randomized Controlled Trial Multicenter Study Clinical Trial
Investigation and management of iron deficiency anaemia in general practice: a cluster randomised controlled trial of a simple management prompt.
Iron deficiency anaemia (IDA) remains the most common cause of anaemia and is frequently secondary to occult gastrointestinal blood loss requiring further investigation. The study was designed to prospectively assess the adequacy of investigation of IDA and to establish whether a simple computerised prompt would increase the completeness of investigation of patients presenting to their general practitioners. ⋯ The investigation and management of IDA presenting in general practice remains inadequate and is not improved by a simple management prompt.
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Randomized Controlled Trial Comparative Study Clinical Trial
Intraoperative glove perforation--single versus double gloving in protection against skin contamination.
Surgeons have the highest risk of contact with patients' blood and body fluids, and breaches in gloving material may expose operating room staff to risk of infections. This prospective randomised study was done to assess the effectiveness of the practice of double gloving compared with single gloving in decreasing finger contamination during surgery. In 66 consecutive surgical procedures studied, preoperative skin abrasions were detected on the hands of 17.4% of the surgeons. ⋯ An overwhelming majority of glove perforations (83.3%) went unnoticed. Double gloving was accepted by the majority of surgeons, especially with repeated use. It is recommended that double gloves are used routinely in all surgical procedures in view of the significantly higher protection it provides.