Stroke; a journal of cerebral circulation
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Meta Analysis
Impact of fever on outcome in patients with stroke and neurologic injury: a comprehensive meta-analysis.
Many studies associate fever with poor outcome in patients with neurological injury, but this relationship is blurred by divergence in populations and outcome measures. We sought to incorporate all recent scholarship addressing fever in brain-injured patients into a comprehensive meta-analysis to evaluate disparate clinical findings. ⋯ In the pooled analyses covering 14431 patients with stroke and other brain injuries, fever is consistently associated with worse outcomes across multiple outcome measures.