Stroke; a journal of cerebral circulation
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Randomized Controlled Trial
Mild hypothermia after intravenous thrombolysis in patients with acute stroke: a randomized controlled trial.
Hypothermia improves outcome in resuscitated patients and newborns with hypoxic brain injury. We studied the safety and feasibility of mild hypothermia in awake patients with stroke after intravenous thrombolysis. ⋯ http://www.clinicaltrials.gov. Unique identifier: NCT00987922.
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Randomized Controlled Trial
Alberta Stroke Program early computed tomography score to select patients for endovascular treatment: Interventional Management of Stroke (IMS)-III Trial.
The Interventional Management of Stroke (IMS)-III trial randomized patients with acute ischemic stroke to intravenous tissue-type plasminogen activator (tPA) plus endovascular therapy versus intravenous tPA therapy alone within 3 hours from symptom onset. A predefined secondary hypothesis was that subjects with significant early ischemic change on the baseline scan would not respond to endovascular therapy. ⋯ http://www.clinicaltrials.gov. Unique identifier: NCT00359424.
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Randomized Controlled Trial
Early aphasia rehabilitation is associated with functional reactivation of the left inferior frontal gyrus: a pilot study.
Early poststroke aphasia rehabilitation effects and their functional MRI (fMRI) correlates were investigated in a pilot, controlled longitudinal study. ⋯ Early poststroke aphasia treatment is useful, has durable effects, and may lead to early enhanced recruitment of brain areas, particularly the left inferior frontal gyrus, which persists in the chronic phase.
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Randomized Controlled Trial
Carotid stenting: is there an operator effect? A pooled analysis from the carotid stenting trialists' collaboration.
Randomized clinical trials show higher 30-day risk of stroke or death after carotid artery stenting compared with surgery. We examined whether operator experience is associated with 30-day risk of stroke or death in the Carotid Stenting Trialists' Collaboration database. ⋯ Carotid stenting should only be performed by operators with annual procedure volume ≥6 cases per year.