JAMA dermatology
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Randomized Controlled Trial
Effect of Needle Size on Pain Perception in Patients Treated With Botulinum Toxin Type A Injections: A Randomized Clinical Trial.
Transcutaneous injection through smaller hollow-bore needles may decrease patient discomfort, but current evidence is equivocal. ⋯ For facial injections of neurotoxin in saline, 30-gauge needles were associated with greater incidence of clinically significant pain than 32-gauge needles. For patients prone to experience clinically significant pain with facial injections, use of 32-gauge needles may minimize this discomfort.